MODELS AND SERVICES
We have a number of different pre-clinical platforms including in vivo experimental models of lung, liver and renal fibrosis
Unilateral Ureter Obstruction (UUO)
Methionine Choline-Deficient Diet (MCD)
Acute Carbon Tetracholride (CCl4)
Chronic Carbon Tetracholride (CCl4)
Bile duct ligation (BDL)
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Precision Cut Liver Slices (PCLS)
We have patented a precision cut liver slice technology where we are able to keep human or rodent liver slices in intact and active state for minimally 7 days.
Fibrofind has optimised induction of fibrogenesis in these PCLS using specific set of stimuli, which we are able to readily block using an inhibitor, this providing a positive control for any treatment that you may want us to test
Staining & Imaging
we carry out molecular biology service including chromatin immuno-precipitation assays, laser micro dissection using histological slides from human and rodent organs as well DNA methylation analysis in tissues.