MODELS AND SERVICES

We have a number of different pre-clinical platforms including in vivo experimental models of lung, liver and renal fibrosis

Kidney
  • Unilateral Ureter Obstruction (UUO)

Liver
  • Methionine Choline-Deficient Diet (MCD)

  • Acute Carbon Tetracholride (CCl4)

  • Chronic Carbon Tetracholride (CCl4)

  • Bile duct ligation (BDL)

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Lung
  • Bleomycin

Precision Cut Liver Slices (PCLS)

We have patented  a precision cut liver slice technology where we are able to keep human or rodent liver slices in intact and active state for minimally 7 days.

Fibrofind has optimised induction of fibrogenesis in these PCLS using specific set of stimuli, which we are able to readily block using an inhibitor, this providing a positive control for any treatment that you may want us to test

Staining & Imaging

we carry out molecular biology service including chromatin immuno-precipitation assays, laser micro dissection using histological slides from human and rodent organs as well DNA methylation analysis in tissues.